Isis appears in only one episode, Yet Another Side of Me. She is a famous singer who constantly changes her appearance and her music style. She has the same dressmaker as Hannah, Dahliano, where she meets Hannah and tells her that she has to change her style too. At the end of the episode, Isis wears the same outfit as Hannah, copying her style.
Isis is a parody of Madonna. Several songs of hers are mentioned by Miley and Lilly: "Immaterial Girl" (parody of "Material Girl") and "Impress Yourself" (parody of "Express Yourself").
Isis is portrayed by Rachel York.
- Isis' name was censored to "Ice" in some subsequent airings of Yet Another Side of Me, likely due to her sharing her name with ISIS, an Islamic terrorist organization.